Teriparatide can mediate bone metabolism by inhibiting osteoblast apoptosis, activating bone lining cells and enhancing osteoblast differentiation. The PHT-Ⅰ receptor on the surface of osteoblasts, bone lining cells and bone marrow stromal stem cells was stimulated intermittently by modulating the adenylate cyclase-cyclic adenosine-protein kinase A pathway to promote the differentiation of osteoblasts and prolong the lifespan of osteoblasts. The proliferation of osteoblast cell lines was stimulated through the ChemicalbookC signaling pathway of phosphate C-cytoplasmic calcium ion protein kinase. By inhibiting the trans-activation activity of PPARγ, the differentiation of stromal cells into adipocyte lines was reduced, and the number of osteoblasts was increased. Indirectly regulate bone growth by regulating cytokines, for example, iGF-1 can be induced to bind to osteoblasts, thereby promoting bone formation; The process of bone formation is regulated by Wnt signaling pathway, thereby increasing bone formation.

Teriparatide can mediate bone metabolism by inhibiting osteoblast apoptosis, activating bone lining cells and enhancing osteoblast differentiation. The PHT-Ⅰ receptor on the surface of osteoblasts, bone lining cells and bone marrow stromal stem cells was stimulated intermittently by modulating the adenylate cyclase-cyclic adenosine-protein kinase A pathway to promote the differentiation of osteoblasts and prolong the lifespan of osteoblasts. The proliferation of osteoblast cell lines was stimulated through the ChemicalbookC signaling pathway of phosphate C-cytoplasmic calcium ion protein kinase. By inhibiting the trans-activation activity of PPARγ, the differentiation of stromal cells into adipocyte lines was reduced, and the number of osteoblasts was increased. Indirectly regulate bone growth by regulating cytokines, for example, iGF-1 can be induced to bind to osteoblasts, thereby promoting bone formation; The process of bone formation is regulated by Wnt signaling pathway, thereby increasing bone formation.