After more than 10 years of research and development, Liraglutide has many effects such as promoting islet cell regeneration, lowering blood sugar, reducing weight and protecting the cardiovascular system. The brand name VChemicalbookictoza is used to treat type 2 diabetes, and the brand name Saxenda is used to treat chronic obesity as a supplement for diet control and physical exercise

Type 2-diabetes mellitus(T2DM) is a progressive disease associated with significant morbidity and mortality. Glucagon like peptide-1(GLP-1) is an incretin hormone secreted from the small intestine that lowers fasting and postprandial glucose through multiple mechanisms including glucose-dependent insulin secretion, reduction of glucagon secretion, delaying gastric emptying and increased satiety^[1-4]. Liraglutide, a human glucagon-like peptide 1(GLP-1) analogue is a treatment for T2DM that is administered as a once-daily subcutaneous injection. Liraglutide is a GLP-1 analog in which lysine at position 34 has been replaced with arginine, and palmitic acid has been attached via glutamoyl spacer to lysine at position 26^[1-4]. No animal-derived raw materials or excipients are used in the production of liraglutide. The drug product is a solution for subcutaneous injection containing 6.0 mg/ml of the drug substance presented in a pre-filled, multi-dose pen-injector. Unlike GLP-1, liraglutide has a pharmacokinetic and pharmacodynamic profile in human suitable for once daily administration. Following subcutaneous administration, the protracted action profile is based on three mechanisms: self-association, which results in slow absorption, binding to albumin and stability toward the DPP-4 enzyme both resulting in a prolonged plasma half-life. The analog is produced as the polypeptide precursor by r-DNA technology with Saccharomyces cerevisiae strain YES2085 as the production strain. The peptide is acylated with a fatty acid chain during down-stream processing^[1-4].